Incubator Accessories
Diagnostic Biosystems PAPANICOLAOU RED STAIN KIT Papanicolaou Red Stain Kit
The Papanicolaou (PAP) Stain Kit is designed to differentiate between a variety of cells in vaginal smears for detection of vaginal, uterine and cervical cancer.
Diagnostic Biosystems VON KOSSA Von Kossa
The Calcium Stain Kit (Modified Von Kossa) is intended for use in the histological visualization of calcium deposits in paraffin sections.
Diagnostic Biosystems PMS2 PMS2
Postmeiotic segregation increased 2 or PMS2 was originally discovered in S. cerevisiae and is part of the mismatch repair system. It resides on 7p22.2 and its gene product partners with MLH1 to help detect mismatches in DNA. Mutations in PMS2 have been reported in about two percent of families with Lynch syndrome (hereditary nonpolyposis colorectal cancer).
Diagnostic Biosystems CYCLIN D1 Cyclin D1 (SP4)
Cyclin D1 or PRAD-1 or bcl-1 is one of the key cell cycle regulators, and functions in association with cdk4 and/or cdk6 by phosphorylating the Rb protein. It is a putative proto-oncogene overexpressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL).
Diagnostic Biosystems CD23 CD23 (SP23)
This antibody recognizes CD23. CD23 is a 45kDa glycoprotein, which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukemia and some cases of centroblastic/centrocytic lymphoma.
Diagnostic Biosystems HistoZyme
HistoZyme is a proteolytic enzyme solution that results in superior staining over traditionally used enzyme pretreatments, such as pepsin and trypsin. Moreover, HistoZyme requires only a brief incubation at room temperature. Performing antigen recovery with HistoZyme, will allow you to dilute the primary antibody 5 to 10 fold further and achieve optimal staining.\n\nFormalin fixation of tissues induces protein cross links that helps in maintaining the cellular morphology by inactivating the digestive enzymes and preserving the cytoskeleton. Fixation stops tissue autolysis, preserves tissue structures, and immobilizes antigens. However, antigens undergo chemical alteration of their primary, secondary and tertiary structures during fixation.
Diagnostic Biosystems P40 p40
p40 is a relatively unknown antibody that recognizes ΔNp63-a p63 isoform suggested to be highly specific for squamous/basal cells. In a recent study, p40 is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to p63 in specificity1, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. These findings strongly support the routine use of p40 in place of p63 for the diagnosis of pulmonary squamous cell carcinoma.
Diagnostic Biosystems HHV8 HHV8
HHV 8 encodes a latent nuclear antigen (LNA), which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product, which may be related to its oncogenic activity. HHV8 is associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of nonHodgkin lymphoma affecting the body cavities), and multicentric Castleman's disease. HHV 8 is the likely etiological agent of Kaposi’s sarcoma.
Diagnostic Biosystems MONO AEC/PLUS Mono AEC/Plus
Mono AEC/Plus is a single, highly stable, working AEC chromogen/substrate liquid solution. When used in conjunction with immunoperoxidase staining, AEC produces a red colored end product at the positive sites, yielding strong contrast when combined with a blue hematoxylin counter stain. AEC has been well accepted amongst pathologists because of its relatively less toxic nature as compared to DAB. Specimens stained using Mono AEC/Plus cannot be dehydrated in ethanol and hence need to be mounted in an aqueous-based mounting medium such as CC Mount (DBS catalog # K002).
Thermco Products Inc Special application Non-Hg, Spirit, w/safety coat, 34.5 deg./46 deg.C, 0.1C div, 76mm imm, 240mm
These spirit-filled glass thermometer with PTFE coating meets the EPA requirements. Coliform incubator thermometers are designed to use in incubators or baths during coliform tests. Use them to monitor equipment. Each includes an individual serial number and certificate of accuracy. The ACC713BLS can be certified and made traceable to N.I.S.T.
Diagnostic Biosystems BROAD SPECTRUM Broad Spectrum Negative Control
Negative controls are used to determine the specificity of an antibody. No staining should be observed when the primary antibody is omitted. This product is specifically designed to work with rabbit, mouse and goat antibodies. The Broad Spectrum Negative Control has been titered to work with Polymer-based Secondary Systems in manual and automated IHC platforms. This product is specifically designed to work with rabbit, mouse and goat antibodies. The Broad Spectrum Negative Control has been titered to work with Polymer-based Secondary Systems in manual and automated IHC platforms.
Diagnostic Biosystems FLUOROMOUNT/PLUS Fluoromount/Plus™
Fluoromount/Plus™ is an innovative, aqueous-based mounting medium designed especially for the permanent preservation of fluorescent specimens. Fluoromount/Plus™is to be used with tissue sections stained with a multitude of fluorescent dyes. This product is compatible with FITC, phycoerythrin, phycocyanin and allophycocyanin. It can also be used with other fluorescent markers such as Texas Red and rhodamine.\n\nMounting tissue specimens stained with fluorescent dyes.
Caron Products And Services Universal Condensate Recirculating System; 230V, 50/60Hz
These recirculators act as a water delivery system for use with any Caron humidity controlled chamber.
Diagnostic Biosystems MLH-1 MLH-1
The G168-15 antibody recognizes human and mouse MLH1 (80-85kDa). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 isinvolved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it isjoined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.